Dynamic Changes in Myofibroblasts Affect the Carcinogenesis and Prognosis of Bladder Cancer Associated With Tumor Microenvironment Remodeling

• DOI: 10.3389/fcell.2022.833578
• Publication Date: 2022-03-02T06:14:41Z
• Authors: YiHeng Du; YiQun Sui; Jin Cao; Xiang Jiang; Yi Wang; Jiang Yu; Bo Wang; XiZhi Wang; BoXin Xue
• Keywords: Tumor progression; Cancer-Associated Fibroblasts

Bladder cancer (BLCA) is a tumor that possesses significant heterogeneity, and the microenvironment (TME) plays an important role in development of BLCA. The TME chiefly consists cells tumor-infiltrating immune admixed with stromal components. Recent studies have revealed components, especially cancer-associated fibroblasts (CAFs), affect cell infiltration modulate extracellular matrix BLCA, ultimately impacting prognosis therapeutic efficacy Among subgroups CAFs, myofibroblasts (myCAFs) were most abundant demonstrated to play essential affecting various tumors, including However, dynamic changes myCAFs during carcinogenesis progression been less discussed previously. With help bioinformatics algorithms, we roles BLCA this manuscript. Our study highlighted pathogenesis was accompanied by decrease abundance myCAFs, revealing potential protective properties Meanwhile, reduced expressions marker genes highly accurate predicting tumorigenesis. In contrast, also regulated remodeling, metabolism, stemness, oncological mutations, treatment responsiveness patients. Thus, our research bimodal which may be associated temporal change TME. in-depth provide diagnostic biomarkers targets for