The Centriole’s Role in Miscarriages

• DOI: 10.3389/fcell.2022.864692
• Publication Date: 2022-03-01T08:09:46Z
• Authors: Tomer Avidor-Reiss; Luke Achinger; Rustem Uzbekov
• Keywords: Centriole; Male pronucleus; Pronucleus; Axoneme

Centrioles are subcellular organelles essential for normal cell function and development; they form the cell's centrosome (a major cytoplasmic microtubule organization center) cilium sensory motile hair-like cellular extension). with evolutionarily conserved characteristics found in most animal types but absent egg cells exhibit unexpectedly high structural, compositional, functional diversity sperm cells. As a result, centriole's precise role fertility early embryo development is unclear. The centrioles spermatozoan neck, strategic location connecting two central units: tail, which propels to head, holds paternal genetic material. neck an ideal site evolutionary innovation as it can control tail movement pre-fertilization male pronucleus' behavior post-fertilization. We propose that human, bovine, other mammals-which ancestral centriole-dependent reproduction centrioles, where one canonical centriole maintained, atypical formed-adapted extensive species-specific centriolar features. these have post-fertilization malfunction rate, resulting aneuploidy, miscarriages. In contrast, house mice evolved centriole-independent reproduction, losing overcoming mechanism causes