Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses

• DOI: 10.3389/fcell.2022.956265
• Publication Date: 2022-07-15T05:00:47Z
• Authors: Yunqi Huang; Yunjia Liu; Yulu Wu; Yiguo Tang; Mengting Zhang; Siyi Liu; Liling Xiao; Shiwan Tao; Min Xie; Minhan Dai; Mingli Li; Hongsheng Gui; Qiang Wang
• Keywords: Genome-wide Association Study; Genetic Association; SNP

Aim: Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the structure BD subtypes. We aimed to investigate overlap and distinction type I (BD I) & II II) by conducting integrative post-GWAS analyses. Methods: utilized single nucleotide polymorphism (SNP)-level approaches uncover correlated distinct loci. Transcriptome-wide (TWAS) were then approached pinpoint functional genes expressed in specific brain tissues blood. Next, we performed cross-phenotype analysis, including exploring potential causal associations between two subtypes lithium responses comparing difference structures among four different psychiatric traits. Results: SNP-level three genomic loci, SLC25A17, ZNF184, RPL10AP3, shared II, one locus (MAD1L1) significant gene sets involved calcium channel activity, neural synapsed signals that distinguished TWAS data implicated affecting through expression regions (nucleus accumbens for I). Cross-phenotype indicated share continuous with schizophrenia major depressive disorder, which help fill gaps left dichotomy mental disorders. Conclusion: These combined evidences illustrate convergence divergence provide an underlying biological trans-diagnostic insight into