Analysis of pregnancy outcomes in patients with recurrent implantation failure complicated with chronic endometritis

• DOI: 10.3389/fcell.2023.1088586
• Publication Date: 2023-02-13T07:46:15Z
• Authors: Jie Li; Xueyao Li; Jinli Ding; Jing Zhao; Jiao Chen; Feng Guan; Haiyu Deng; Mengqi Zhou; Yiling Han; Zhuoni Xiao; Jing Yang
• Keywords: Endometritis; Live birth

Chronic endometritis (CE) has been considered to reduce uterine receptivity and negatively affect reproductive outcomes for in vitro fertilization-embryo transfer (IVF-ET) patients, especially people undergoing recurrent implantation failure (RIF). To investigate the effects of antibiotic platelet-rich plasma (PRP) therapy on pregnancy following frozen-thawed embryo (FET) RIF patients with CE, endometrial specimens 327 obtained by scratching during mid-luteal phase were immunostained multiple myeloma oncogene-1 (Mum-1)/syndecan-1 (CD138). CE given antibiotics PRP treatment. According Mum-1+/CD138+ plasmacytes after treatment, divided into persistent weak positive (+) group, (-) group non-CE group. FET was performed basic characteristics three groups compared. Among 117 complicated prevalence 35.78%. The strong 27.22% that 8.56%. 70.94% converted negative There no significant difference characteristics, including age, BMI, AMH, AFC, infertility years, types, number previous transplant cycles, thickness transplantation day transplanted embryos (p > 0.05); rate hCG, clinical significantly increased compared < .01), live birth also improved .05). Whereas, early abortion 12.70%, which higher than After multivariate analysis, failed cycles remained independent factors associated rate, while only be factor rate. It is recommended perform CE-related examination RIF. Antibiotic treatment can improve conversion cycle.