The role of microRNA-325-3p as a critical player in cell death in NSCs and astrocytes

• DOI: 10.3389/fcell.2023.1223987
• Publication Date: 2024-01-16T04:16:22Z
• Authors: Yukyeong Lee; Seung-Won Lee; Dahee Jeong; Hye Jeong Lee; Kinarm Ko
• Keywords: Cell and Developmental Biology; 0303 health sciences; 03 medical and health sciences; microRNA; QH301-705.5; proliferation; astrocytes; apoptosis; differentiation; Biology (General); neural stem cells

Neural stem cells (NSCs) are defined by their ability to self-renew and generate various cell types within the nervous system. Understanding underlying mechanism which NSCs proliferate differentiate is crucial for efficient modulation of in vivo neurogenesis. MicroRNAs small non-coding RNAs controlling gene expression concerned post-transcriptional control blocking messenger RNA (mRNA) translation or degrading mRNA. play a role as modulators matching target mRNAs. Recent studies have discussed biological microRNA regulation To investigate microRNAs NSC-derived glial cells, we screened out NSC-specific using miRNome-wide screening. Then, induced downregulation sponge against specific evaluate functional proliferation, differentiation, apoptosis astrocytes. We found that microRNA-325-3p highly expressed Furthermore, showed regulator targeting brain-specific angiogenesis inhibitor (BAI1), receptor apoptotic brain cultured Downregulation an inducible system death regulating BAI1 Overall, our findings can provide insight into potential roles neurogenesis suggest possible usage biomarkers neurodegenerative disease.