Navigating the brain and aging: exploring the impact of transposable elements from health to disease

• DOI: 10.3389/fcell.2024.1357576
• Publication Date: 2024-02-27T04:36:23Z
• Authors: Anna Le Breton; Margarida P. Bett...; Anne-Valerie Gendrel
• Keywords: 0301 basic medicine; LINE-1; Cell and Developmental Biology; 03 medical and health sciences; epigenetics; QH301-705.5; brain; aging; neurological disorders; transposable elements; Biology (General)

Transposable elements (TEs) are mobile genetic that constitute on average 45% of mammalian genomes. Their presence and activity in genomes represent a major source variability. While this is an important driver genome evolution, TEs can also have deleterious effects their hosts. A growing number studies focused the role brain, both physiological pathological contexts. In believed to be for neuronal plasticity. neurological age-related disorders, aberrant may contribute disease etiology, although remains unclear. After providing comprehensive overview transposable interactions with host, review summarizes current understanding TE within during aging process, context conditions.