Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma

• DOI: 10.3389/fcell.2024.1375030
• Publication Date: 2024-04-11T04:36:35Z
• Authors: Zhen Liu; Liangwang Yang; Wenqi Wu; Zejun Chen; Zhengxing Xie; Daoming Shi; Ning Cai; Shenghua Zhuo
• Keywords: Gene signature

Background Glioma is the most common cancer of central nervous system with poor therapeutic response and clinical prognosis. Insulin-like growth factor 1 receptor ( IGF-1R ) signaling implicated in tumor development progression induces apoptosis cells following functional inhibition. However, relationship between -related pathway genes glioma prognosis or immunotherapy/chemotherapy poorly understood. Methods LASSO–Cox regression was employed to develop a 16-gene risk signature TCGA-GBMLGG cohort, all patients were divided into low-risk high-risk subgroups. The relationships immune microenvironment (TIME), immunotherapy response, chemotherapy then analyzed. Immunohistochemistry used evaluate HSP90B1 level tissue. Results gene yielded superior predictive efficacy (5-year area under curve: 0.875) can therefore serve as an independent prognostic indicator glioma. subgroup exhibited abundant infltration elevated checkpoint expression within TIME. Subsequent analysis revealed that benefited more from chemotherapy. Immunohistochemical confirmed overexpressed glioma, significantly higher levels observed glioblastoma than astrocytoma oligodendrocytoma. Conclusion newly identified demonstrates robust capacity for plays pivotal role TIME, thereby offering valuable insights exploration novel biomarkers targeted therapeutics.