Relapse or Re-Infection, the Situation of Recurrent Tuberculosis in Eastern China

• DOI: 10.3389/fcimb.2021.638990
• Publication Date: 2021-03-17T05:35:14Z
• Authors: Yan Shao; Honghuan Song; Guoli Li; Yan Li; Yishu Li; Limei Zhu; Wei Lu; Cheng Chen
• Keywords: relapse; re-infection; China; recurrence; Genotype; Antitubercular Agents; Minisatellite Repeats; Mycobacterium tuberculosis; Microbiology; QR1-502; 3. Good health; MIRU-VNTR; 03 medical and health sciences; Cellular and Infection Microbiology; 0302 clinical medicine; tuberculosis; Recurrence; Drug Resistance, Multiple, Bacterial; Reinfection; Humans; Tuberculosis

Purpose Recurrent tuberculosis (TB) is defined by more than one TB episode per patient and caused re-infection with a new Mycobacterium (Mtb) strain or relapse the previous strain. Recurrence of important obstacle for End strategy in world elucidating triggers recurrence current control China. This study aimed to analyze sources recurrent molecular genotyping method. Method A population-based surveillance was undertaking on all culture-positive cases Jiangsu province, China from 2013 2019. Phenotypic drug susceptibility test (DST) proportion method mycobacterial interspersed repetitive units-variable number tandem repeat (MIRU-VNTR) were adopted resistance genotype detection. Results total 1451 patients collected 30 (2.06%, 30/1451) had episodes. Except 7 isolates failed during subculture, 23 paired assessed. After MIRU-VNTR, 12 (52.17%, 12/23) demonstrated as 11 (47.83%,11/23) identified re-infection. The average interval time 24.04 (95%CI: 19.37-28.71) months, there no significant difference between For relapsed cases, two exhibited shifting, while four revealed inconsistent among group including multidrug-resistant (MDR-TB) at second episode. Conclusion Relapse contributed equally situation Jiangsu, Besides, efficient treatment assessment, specific vigorous interventions are urgently needed MDR-TB patients, considering obvious performance cases.