Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

• DOI: 10.3389/fcimb.2021.652617
• Publication Date: 2021-05-03T05:10:12Z
• Authors: Kari E. Murros; Vy A. Huynh; Timo M. Takala; Per E. J. Saris
• Keywords: Desulfovibrio; Pathogenesis

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects elderly. It a progressive neurodegenerative wherein α-synuclein, neuronal protein, aggregates to form toxic structures in nerve cells. The cause of remains unknown. Intestinal dysfunction changes gut microbiota, common symptoms PD, are evidently linked pathogenesis PD. Although multitude studies have investigated microbial etiologies role progression unclear. Here, we show that Gram-negative sulfate-reducing bacteria genus Desulfovibrio may play potential development Conventional quantitative real-time PCR analysis feces from twenty PD patients healthy controls revealed all harbored their microbiota these were present at higher levels than controls. Additionally, concentration species correlated with severity produce hydrogen sulfide lipopolysaccharide, several strains synthesize magnetite, which likely induce oligomerization aggregation α-synuclein protein. substances originating take part These findings open new avenues for treatment identification people risk developing