Efficacy of Ebselen Against Invasive Aspergillosis in a Murine Model

• DOI: 10.3389/fcimb.2021.684525
• Publication Date: 2021-06-23T05:49:05Z
• Authors: Karina Mayumi Sakita; Isis Regina Greni...; Pollyanna Cristin...; Franciele Abigail...; Daniella Renata F...; Glaucia Sayuri Arita; Tânia Cristina Al...; Patricia de Souza...; Terezinha Inez Es...; Erika Seki Kioshima
• Keywords: Ebselen

Invasive aspergillosis is one of the major causes morbidity and mortality among invasive fungal infections. The search for new antifungal drugs becomes imperative when existing are not able to efficiently treat these Ebselen, an organoselenium compound, already successfully approved in clinical trials as a repositioned drug treatment bipolar disorder prevention noise-induced hearing loss. In this study, we aimed reposition ebselen by showing effectiveness murine model. For this, BALB/c mice were immunosuppressed infected systemically with Aspergillus fumigatus. Animals divided treated ebselen, voriconazole, or drug-free control, four days. kidneys used CFU count and, histopathological cytokine analysis. Ebselen was significantly reduce burden efficacy comparable voriconazole both had reductions same extent. absence hyphae intact kidney tissue structure observed sections analyzed from groups corroborate downregulation IL-6 TNF. summary, study brings first time vivo evidence against aspergillosis. Despite promising results, more animal studies warranted evaluate potential role alternative option management humans.