Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers

• DOI: 10.3389/fcimb.2021.774665
• Publication Date: 2021-12-24T05:04:56Z
• Authors: Elisa Kopra; Laura Lahdentausta; Milla Pietiäinen; Kåre Buhlin; Päivi Mäntylä; Sohvi Hörkkö; Rutger Persson; Susanna Paju; Juha Sinisalo; Aino Salminen; Pirkko J. Pussinen
• Keywords: Bleeding on probing

The use of systemic antibiotics may influence the oral microbiota composition. Our aim was to investigate in this retrospective study whether prescribed associate with periodontal status, microbiota, and antibodies against pathogens. Social Insurance Institution Finland Data provided data on by record linkage purchased medications entitled reimbursements up 1 year before examination sampling. Six different classes were considered. Parogene cohort included 505 subjects undergoing coronary angiography mean (SD) age 63.4 (9.2) years 65% males. Subgingival plaque samples analysed using checkerboard DNA-DNA hybridisation. Serum saliva antibody levels pathogens immunoassays lipopolysaccharide (LPS) activity LAL assay. Systemic for 261 (51.7%) patients during preceding year. number prescriptions among them 2.13 (range 1–12), 29.4% cephalosporins, 25.7% penicillins, 14.3% quinolones, 12.7% macrolides or lincomycin, 12.0% tetracycline, 5.8% trimethoprim sulphonamides. In linear regression models adjusted age, sex, current smoking, diabetes, antibiotic courses associated significantly low inflammation burden index (PIBI, p < 0.001), bleeding probing (BOP, = 0.006), alveolar bone loss (ABL, 0.042). Cephalosporins all parameters. phyla mainly affected Bacteroidetes Spirochaetes. Their inversely ( 0.010 0.001) directly time since last prescription 0.019 0.001). Significant inverse associations observed between concentrations Prevotella intermedia , Tannerella forsythia Treponema denticola subgingival bacterial amounts Porphyromonas gingivalis P. T. . Saliva serum did not present an association antibiotics. Both 0.031) 0.032) LPS lower having any course less than month have effects composition, whereas host immune responses biomarker species seem unchanged.