Feline Panleukopenia Virus With G299E Substitution in the VP2 Protein First Identified From a Captive Giant Panda in China

• DOI: 10.3389/fcimb.2021.820144
• Publication Date: 2022-02-07T14:17:20Z
• Authors: Shushuai Yi; Songrui Liu; Xianyong Meng; Pei Huang; Zengguo Cao; Hongli Jin; Jianzhong Wang; Guixue Hu; Jingchao Lan; Dongsheng Zhang; Yuwei Gao; Hualei Wang; Nan Li; Na Feng; Rong Hou; Songtao Yang; Xianzhu Xia
• Keywords: Diarrhea; 0301 basic medicine; China; FPV; VP2 protein; Microbiology; QR1-502; 3. Good health; giant pandas; molecular characterization; Parvoviridae Infections; 03 medical and health sciences; Cellular and Infection Microbiology; Animals; Animals, Zoo; Capsid Proteins; Feline Panleukopenia Virus; Phylogeny; Ursidae; G299E

A feline panleukopenia virus (FPV), Giant panda/CD/2018, was isolated from a captive giant panda with mild diarrhea in 2018 Chengdu, China, and further identified via indirect immunofluorescence assay (IFA), transmission electron microscopy (TEM) observation, genetic analysis. Phylogenetic analysis based on the complete VP2 nucleotide sequences showed that it shared high homology Chinese FPV isolates grouped within cluster 1. One unique substitution Gly(G)299Glu(E) capsid protein first panda/CD/2018. The presence of G299E is notable as located top region interconnecting surface loop 3, which may be involved controlling host range antigenicity FPV. These findings demonstrate natural point mutation gene prevalent suggest etiological surveillance vaccination among all pandas are urgently needed to protect this endangered species against infection.