Fecal Microbiota Transplantation Alters the Outcome of Hepatitis B Virus Infection in Mice

• DOI: 10.3389/fcimb.2022.844132
• Publication Date: 2022-05-04T07:29:35Z
• Authors: Junzhong Wang; Xin Zhou; Xiaoran Li; Weina Guo; Qingfeng Zhu; Bin Zhu; Yinping Lu; Xin Zheng; Dongliang Yang; Baoju Wang
• Keywords: Fecal bacteriotherapy

The susceptibility of mice to hepatitis B virus (HBV) infection depends on their genetic background. gut microbiota modulates the antiviral immune response in liver and plays a protective role against HBV infection. However, whether outcomes depend remains unclear. In this study, we assessed composition naïve BALB/c C57BL/6 using 16S rRNA gene sequencing. was depleted broad-spectrum antibiotics (ABX) then reconstituted with fecal from or evaluate effect transplantation (FMT) We found that differed between mice. Commensal bacteria selectively colonized guts ABX-treated Mice receiving displayed different outcomes. induced tolerance prolonged conclusion, are determined by host background composition. Reconstitution FMT can alter