SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key

• DOI: 10.3389/fcimb.2022.868414
• Publication Date: 2022-03-24T01:22:12Z
• Authors: Ranjeet Maurya; Pallavi Mishra; Aparna Swaminathan; Varsha Ravi; Sheeba Saifi; Akshay Kanakan; Priyanka Mehta; Priti Devi; Shaista Praveen; Sandeep Budhiraja; Bansidhar Tarai; Shimpa Sharma; Rajesh J. Khyalappa; Meghnad G. Joshi; Rajesh Pandey
• Keywords: Pandemic; Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous burden on the healthcare system worldwide as a consequence of its new emerging variants concern (VOCs) since late 2019. Elucidating viral genome characteristics and influence disease severity clinical outcome been one crucial aspects toward pandemic management. Genomic surveillance holds key to identify spectrum mutations vis-à-vis outcome. Here, in our study, we performed comprehensive analysis mutation distribution among 2019 (COVID-19) recovered mortality patients. In addition data analysis, significant within two groups were analyzed for their global presence effort understand temporal dynamics globally comparison with cohort. Interestingly, found that all patients showed significantly low presence, indicating possibility regional pool absence preferential selection by virus during course pandemic. addition, S194L have most occurrence group, suggesting role severe progression. Also, discovered three high cohort distribution, which later became part interest (VOIs)/VOCs, enhancing characteristics. To possible mechanism, molecular (MD) simulations nucleocapsid mutations, S194*, from patients, respectively, examine impacts protein structure stability. Importantly, observed S194* be comparatively unstable, hence showing frequency, observed. Thus, study provides integrative insights about features, associated different outcomes, effects at structural level driving COVID-19