Mycobacterium avium subsp. paratuberculosis and Hashimoto’s thyroiditis: Is MAP the trigger?

• DOI: 10.3389/fcimb.2022.972929
• Publication Date: 2022-09-20T05:13:30Z
• Authors: Maedeh Moghadam; Ezzat Allah Ghaemi; Hamideh Akbari; Hadi Razavi Nikoo; Samin Zamani
• Keywords: Subclinical infection; Autoimmune thyroiditis

Hashimoto's thyroiditis (HT) is an autoimmune disorder of the thyroid gland that can cause hypothyroidism. As HT a multifactorial disorder, activation immune responses in genetically predisposed individuals exposed to some environmental factors contribute it. Microorganisms, as factors, including Mycobacterium avium ssp. paratuberculosis (MAP) by molecular mimicry, be important this disorder. This study aimed investigate association between MAP and HT. case-control included 110 participants consisting 60 patients 50 healthy controls (HCs). Blood samples were collected. Nested PCR IS900 gene determined presence DNA. The enzyme-linked immunosorbent assay (ELISA) was designed identify antibodies (Abs) against MAP3865c epitope, which has homologous sequence with ZnT8 sera. demographic information all recorded. Anti-TG, anti-TPO, TSH, anemia, ruminant exposure higer than HCs (p < 0.05). detected significantly more (46.6% 30, 8.3, 8.3% clinical, subclinical, unknown) (14%). sera showed remarkable frequency reactivity (38.3%) comparison (10%) = 0.0001). Furthermore, higher rate livestock contact traditional dairy consumption found or anti-MAP3865c Abs positive result suggests possible link These findings indicated not statistically different severity its shift into clinical subclinical forms; therefore, it could assumed MAPs are initiators process. results imply on zoonosis transmission route from products humans. Further research needed confirm these larger groups patients.