Metatranscriptomic analysis revealed Prevotella as a potential biomarker of oropharyngeal microbiomes in SARS-CoV-2 infection

• DOI: 10.3389/fcimb.2023.1161763
• Publication Date: 2023-06-02T12:44:26Z
• Authors: Sifen Lu; Yongzhao Zhou; Ya Hu; Jing Wang; Honghao Li; Yifei Lin; Denian Wang; Jinghong Xian; Shengmei Zhao; Jinmin Ma; Zhongyi Zhu; Shengying Yang; Qinghui Meng; Yulin Kang; Bojiang Chen; Weimin Li
• Keywords: Prevotella; Coronavirus

Background and objectives Disease severity prognosis of coronavirus disease 2019 (COVID-19) with other viral infections can be affected by the oropharyngeal microbiome. However, limited research had been carried out to uncover how these diseases are differentially microbiome patient. Here, we aimed explore characteristics microbiota COVID-19 patients compare them those similar symptoms. Methods was diagnosed in through detection severe acute respiratory syndrome 2 (SARS-CoV-2) quantitative reverse transcription polymerase chain reaction (RT-qPCR). Characterization performed metatranscriptomic sequencing analyses swab specimens from 144 patients, 100 infected viruses, 40 healthy volunteers. Results The diversity SARS-CoV-2 infection different that infections. Prevotella Aspergillus could play a role differentiation between also influence mechanism potentially involved sphingolipid metabolism regulation pathway. Conclusion characterization caused viruses. act as biomarker for diagnosis host immune response evaluation infection. In addition, cross-talk among , SARS-CoV-2, pathways provide basis precise diagnosis, prevention, control, treatment COVID-19.