Chimaeribacter arupi a new member of the Yersineacea family has the characteristics of a human pathogen

• DOI: 10.3389/fcimb.2023.1277522
• Publication Date: 2023-10-06T09:56:27Z
• Authors: Matthias Riediger; Katharina Hoffmann; Riekje Isberner; Annika Dreyer; Aljoscha Tersteegen; Pauline Marquardt; Achim J. Kaasch; Andreas E. Zautner
• Keywords: Chimaeribacter arupi; 0303 health sciences; Base Sequence; Virulence Factors; blood stream infection; Infant; comparative genomics; Microbiology; QR1-502; 03 medical and health sciences; Cellular and Infection Microbiology; Fimbriae, Bacterial; Sepsis; “Nissabacter archeti”; Gram-Negative Bacteria; case report; Humans; Female; genome

Chimaeribacter arupi (heterotypic synonym: "Nissabacter archeti") is a facultative anaerobic, newly described Gram-negative rod and belongs to the Yersineacea family. Here, we report case of 19-month-old female infant patient who presented emergency unit with somnolence fever. C. was isolated from positive blood culture, taken via an implanted Broviac catheter, proving bloodstream infection by pathogen. The objective this study utilize whole genome sequencing assess genes encoding potential virulence associated factors, which may play role in host tropism, tissue invasion subsequent stages pathogenesis arupi. isolate completely sequenced employing Illumina MiSeq Nanopore MinION presumptive factors antimicrobial resistance were investigated more detail. Additionally, performed metabolic profiling susceptibility testing microdilution. presence predicted TcfC-like α-Pili suggests that highly adapted humans as host. It utilizes flagellar type IV pili-mediated motility, well number γ1-pili σ-pilus, be used facilitate biofilm formation adherence epithelia. long polar fimbriae aid invasion. bacterium possesses antioxidant enable temporary survival phagolysosomes, capsule potentially provides protection phagocytosis. acquire iron ions erythrocytes through 6 secretion system hemolysins. Furthermore, exhibits beta-lactamase-mediated penicillin aminopenicillin resistance. Based on analysis genome, conclude thus opportunistic pathogen infections.