The role of inflammasome in chronic viral hepatitis

• DOI: 10.3389/fcimb.2024.1382029
• Publication Date: 2024-05-16T04:52:35Z
• Authors: Pin Wan; Ge Yang; Qi Cheng; Xuelong Zhang; Zhaoyang Yue; Moran Li; Chunlin Liu; Qian Yi; Yaling Jia; Jinbiao Liu; Xiwen Xing; Binlian Sun; Yongkui Li
• Keywords: Pyroptosis; AIM2; Viral Hepatitis; Hepatitis B

Infections of hepatotropic viruses cause a wide array liver diseases including acute hepatitis, chronic hepatitis and the consequently developed cirrhosis hepatocellular carcinoma (HCC). Among five classical viruses, B virus (HBV) C (HCV) usually infect human persistently leading to major troubles humanity. Previous studies have revealed that several types inflammasomes are involved in infections HBV HCV. Here, we summarize current knowledge about their roles C. NLRP3 inflammasome can be activated regulated by It is found exert antiviral function or mediates inflammatory response viral depending on different experimental models. Besides inflammasome, IFI16 AIM2 participate pathological process B, NALP3 may sense HCV infection hepatocytes. The affect through its downstream secretion cytokines interleukin-1β (IL-1β) IL-18 induction pyroptosis resulting from cleaved gasdermin D (GSDMD). However, stages remains mainly unclear. More proper models should for specific future, so understand more complexity regulation multifunction effectors during infections.