Association of glycerolipid metabolism with gut microbiota disturbances in a hamster model of high-fat diet-induced hyperlipidemia

• DOI: 10.3389/fcimb.2024.1439744
• Publication Date: 2024-10-04T07:39:07Z
• Authors: Lijie Han; Chaowei Hu; Zhiyong Du; Huahui Yu; Yunhui Du; Linyi Li; Fan Li; Yu Wang; Xiaoqian Gao; Xuechun Sun; Zihan Zhang; Yanwen Qin
• Keywords: Hyperlipidemia

Background High-fat diet (HFD)-induced hyperlipidemia, which is associated with gut microbiota disturbances, remains a major public health challenge. Glycerolipid metabolism responsible for lipid synthesis and thus involved in the development of hyperlipidemia. However, possible association between HFD-modulated microbiome glycerolipid pathway unclear. Methods Hamsters were fed HFD 4 weeks to establish hyperlipidemia model. Fecal, plasma liver samples collected from hamsters or normal chow (NCD) used integrative metagenomic untargeted metabolomic analyses explore changes composition functions microbiota, relevant metabolites. Spearman rank correlation analysis was correlations microbes circulating metabolites, lipids, metabolites lipids. Results The microbial showed significant alterations at phylum, genus, species levels that skewed toward metabolic disorders compared NCD hamsters. Functional characterization by KEGG identified enrichment Plasma metabolomics further indicated upregulation Faecalibaculum , Allobaculum Eubacterium genera positively correlated indices. Conclusion findings this study suggest an