Regular Dietary Intake of Palmitate Causes Vascular and Valvular Calcification in a Rabbit Model

• DOI: 10.3389/fcvm.2021.692184
• Publication Date: 2021-06-23T06:28:03Z
• Authors: Nathalie Donis; Zheshen Jiang; Céline D'Emal; Raluca Dulgheru; Martin Giera; Niek Blomberg; Philippe Delvenne; Alain Nchimi; Patrizio Lancellotti; Cécile Oury
• Keywords: 2. Zero hunger; blood fatty acids; aortic valve calcification; Cardiovascular Medicine; 3. Good health; 03 medical and health sciences; nutrition; 0302 clinical medicine; vascular calcification; RC666-701; Diseases of the circulatory (Cardiovascular) system; palmitate

Aims: Palmitic acid (PA) and oleic (OA) are two main dietary fatty acids. Dietary intake of PA has been associated with cardiovascular disease risk, the effect OA remains uncertain. Our study aimed to assess a short-term lard, as source OA, on aorta aortic valve. Methods Results: Rabbits were fed lard-enriched diets, containing either elevated levels or both compared chow diet. After 16 weeks each diet, calcification was observed in intima The extent did not differ between diets. In contrast, rabbits diet develop any calcification. blood, enrichment resulted decreased lymphocyte monocyte counts increased hemoglobin haematocrit. Levels inhibitor fetuin-A also diminished, whereas creatinine raised. Of note, none diets changed cholesterol LDL HDL. Comprehensive quantitative lipidomics analysis identified diet-related changes plasma lipids. led drop polyunsaturated acids (PUFA), particular linoleic cholesteryl esters, triglycerides diacylglycerols (DAG). Ratios 18-carbon PUFA DAG positively correlated valve calcification, inversely counts. content blood Conclusions: Regular induces vascular valvular independently traditional risk factors. findings raise awareness about PA-rich food consumption its potential deleterious health.