The Effects of Intermittent Hypoxic–Hyperoxic Exposures on Lipid Profile and Inflammation in Patients With Metabolic Syndrome

• DOI: 10.3389/fcvm.2021.700826
• Publication Date: 2021-09-03T11:17:40Z
• Authors: A. Bestavashvili ...; S. Glazachev Oleg; A. Bestavashvili ...; Dhif Ines; Suvorov Alexander Yu; V. Vorontsov Nikita; S. Tuter Denis; G. Gognieva Daria; Yong Zhang; S. Pavlov Chavdar; V. Glushenkov Dmi...; A. Sirkina Elena; V. Kaloshina Irina; Kopylov Philippe Yu
• Keywords: Lipid Profile; Dyslipidemia

Background: Patients with metabolic syndrome (MS) tend to suffer from comorbidities, and are often simultaneously affected by obesity, dysglycemia, hypertension, dyslipidemia. This can be reversed if it is timely diagnosed treated a combination of risk factors-reducing lifestyle changes tailored pharmacological plan. Interval hypoxic-hyperoxic training (IHHT) has been shown as an effective program in reducing cardiovascular factors patients MS even the absence exercise. However, influence IHHT on lipid profile inflammation this clinical population remains relatively unknown. Methods: A prospective, single-center, randomized controlled trial was conducted 65 (33 men) aged 29–74 years, who were randomly allocated or control (sham) experimental groups. The group completed 3-week, 5 days/week intermittent exposure hypoxia hyperoxia. followed same protocol but breathing room air instead. primary endpoints (concentrations total cholesterol [TC], low-density lipoprotein [LDL], high-density [HDL], triglycerides [TG]) inflammatory such high-sensitivity C-reactive protein (hs-CRP), galectin-3, heat shock proteins (Hsp70). secondary alanine aminotransferase (ALT), aspartate (AST), N-terminal pro-hormone brain natriuretic peptide level (NTproBNP), transforming growth factor beta-1 (TGF-beta1), heart-type fatty acid-binding (H-FABP), nitric oxide synthase 2 (NOS2). Results: There no differences between two groups different baseline values have these results. demonstrated pre-post decrease ( p = 0.001), LDL TG levels 0.001). We also found CRP-hs 0.015) Hsp70 0.006) IHHT-group after intervention, significant (delta) NTproBNP < 0.0001) compared group. In addition, showed statistically ALT AST comparison No complications serious adverse events observed. Conclusions: appears improve anti-inflammatory status. It safe, well-tolerated procedure, could recommended auxiliary treatment suffering MS, however, experiment results limited differences. Clinical Trial Registration: ClinicalTrials.gov , identifier [NCT04791397]. Evaluation effect vascular stiffness elasticity liver tissue MS.