Non-invasive Global and Regional Myocardial Work Predicts High-Risk Stable Coronary Artery Disease Patients With Normal Segmental Wall Motion and Left Ventricular Function

• DOI: 10.3389/fcvm.2021.711547
• Publication Date: 2021-09-28T05:08:25Z
• Authors: Jun Zhang; Yani Liu; Youbin Deng; Ying Zhu; Ruiying Sun; Shirui Lu
• Keywords: Scad; Speckle tracking echocardiography

Background: Previous studies suggested that myocardial work (MW) may identify abnormalities in the left ventricular (LV) function and establish a more sensitive index for LV dysfunction at early stage. This study aimed to explore value of global regional MW parameters predicting high-risk stable coronary artery disease (SCAD) patients with normal wall motion preserved function. Patients Methods: A total 131 patients, who were clinically diagnosed as SCAD function, finally included this study. Global parameters, including (GWI), constructive (GCW), waste (GWW), efficiency (GWE) measured non-invasive pressure-strain loops constructed from speckle-tracking echocardiography. Regional (RWI) (RWE) also calculated according perfusion territory each major artery. All underwent angiography divided into group, non-high-risk No group range degrees arteries stenosis. Results: The longitudinal strain (GLS), GWI GCW statistically different (P < 0.001) among three groups. In GLS, GWI, significantly lower than other two groups 0.05). Receiver operating characteristic analysis demonstrated could predict cutoff 1,808 mm Hg% (sensitivity, 52.6%; specificity, 87.8%; predictive positive value, 76.3%; negative 69.9%) 2,308 80.7%; 64.9%; 63.3%; 80.0%), respectively. Multivariate analyses showed carotid plaque, decreased was independently related SCAD. values RWILAD, RWILCX, RWIRCA 2,156, 1,929, 1,983 SCAD, respectively 0.001). When we combined RWI or regions, diagnostic performance improved Conclusions: Both have great potential non-invasively contributing identification benefit revascularization therapy.