Favorable effect of renal denervation on elevated renal vascular resistance in patients with resistant hypertension and type 2 diabetes mellitus

• DOI: 10.3389/fcvm.2022.1010546
• Publication Date: 2022-12-14T06:30:10Z
• Authors: Musheg Manukyan; Alla Falkovskaya; Victor Mordovin; Stanislav Pekarskiy; Irina Zyubanova; Ekaterina Solonskaya; Tamara Ryabova; Simzhit Khunkhinova; Anastasia Vtorushina; Sergey Popov
• Keywords: renal hemodynamics; type 2 diabetes mellitus; renal resistive index; renal function; resistant hypertension; Cardiovascular Medicine; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; RC666-701; Diseases of the circulatory (Cardiovascular) system; renal denervation

To assess the effect of renal denervation (RDN) on vascular resistance and function in patients with drug-resistant hypertension (HTN) type 2 diabetes mellitus (T2DM). Fifty-nine (mean age 60.3 ± 7.9 years, 25 men) resistant HTN [mean 24-h ambulatory blood pressure (BP) 158.0 16.3/82.5 12.7 mmHg, systolic/diastolic] T2DM HbA1c 7.5 1.5%) were included single-arm prospective study underwent RDN. Renal resistive index (RRI) derived from ultrasound Doppler; estimated glomerular filtration rate (Chronic Kidney Disease Epidemiology Collaboration formula), office BP measured at baseline, 6, 12 months after RDN to evaluate respective changes resistance, function, during treatment. Forty-three completed follow-up. The RRI changed depending baseline value. Specifically, decreased significantly elevated values ≥ 0.7 {n = 23; -0.024 [95% confidence interval (CI): -0.046, -0.002], p 0.035} did not change those < [n 36; 0.024 (95% CI: -0.002, 0.050), 0.069]. No significant was observed eGFR whereas reduced by -10.9 -16.7, -5.0)/-5.5 -8.7, -2.4) systolic/diastolic. relationship found between BP. Our shows that can decrease (RRI > 0.7) stabilize kidney RHTN independently its BP-lowering effect.