Identification of GLS as a cuproptosis-related diagnosis gene in acute myocardial infarction

• DOI: 10.3389/fcvm.2022.1016081
• Publication Date: 2022-11-11T04:36:09Z
• Authors: Zheng Liu; Lei Wang; Qichang Xing; Xiang Liu; Yixiang Hu; Wencan Li; Qingzi Yan; Renzhu Liu; Nan Huang
• Keywords: KEGG; Competing Endogenous RNA

Acute myocardial infarction (AMI) has the characteristics of sudden onset, rapid progression, poor prognosis, and so on. Therefore, it is urgent to identify diagnostic prognostic biomarkers for it. Cuproptosis a new form mitochondrial respiratory-dependent cell death. However, studies are limited on clinical significance cuproptosis-related genes (CRGs) in AMI. In this study, we systematically assessed genetic alterations CRGs AMI by bioinformatics approach. The results showed that six (LIAS, LIPT1, DLAT, PDHB, MTF1, GLS) were markedly differentially expressed between stable coronary heart disease (stable_CAD) Correlation analysis indicated closely correlated with N6-methyladenosine (m6A)-related through R language "corrplot" package, especially GLS was positively FMR1 MTF1 negatively HNRNPA2B1. Immune landscape revealed related various immune cells, T cells CD4 memory resting monocytes. Kaplan-Meier demonstrated group high DLAT expression had better prognosis. area under curve (AUC) certified good value, training set (AUC = 0.87) verification (ACU 0.99). Gene enrichment (GSEA) suggested associated immune- hypoxia-related pathways. addition, Ontology (GO) analysis, Kyoto Encyclopedia Genes Genomes (KEGG) competing endogenous RNA (ceRNA) transcription factor (TF), compound prediction performed reveal regulatory mechanism Overall, our study can provide additional information understanding role AMI, which may insights into identification therapeutic targets