Injury and Healing Response of Healthy Peripheral Arterial Tissue to Intravascular Lithotripsy: A Prospective Animal Study

• DOI: 10.3389/fcvm.2022.787973
• Publication Date: 2022-03-29T23:56:56Z
• Authors: Feng Liu; Yangyang Ge; Dan Rong; Yating Zhu; Jianhan Yin; Guoyi Sun; Xin Jia; Wei Guo
• Keywords: Neointima; Lumen (anatomy); Internal elastic lamina

Intravascular lithotripsy (IVL) is a novel clinical technique for the management of severely calcified lesions. However, biological effects shock wave on healthy arterial tissue have not been demonstrated. The preclinical safety study aimed to investigate vascular response IVL compared plain old balloon angioplasty (POBA) in porcine peripheral arteries.The left and right iliofemoral segments 16 mini-pigs were subjected POBA, respectively. was evaluated using quantitative angiography (QVA), light microscopy, scanning electron microscopy (SEM) at 0, 5, 28 days.With emission wave, adjacent muscle contraction observed. QVA showed there no statistically significant difference percent diameter stenosis late lumen loss between two groups. SEM examination endothelial cell layer intact both groups all timepoints. Under area resulted significantly higher intimal days. Neointima score trend toward rate group, although There differences scored parameters inflammation neointima scores group. After disruption internal elastic lamina, arteries demonstrated neointimal thickening.The operability are comparable POBA. histological mild sustained. do cause serious damage, especially denudation.