Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study

• DOI: 10.3389/fcvm.2022.856160
• Publication Date: 2022-05-02T04:49:47Z
• Authors: Hilla Gerard; Nicolas Iline; Hélène Martel; Karine Nguyen; Pascale Richard; Erwan Donal; Jean-Christophe E...; Olivier Huttin; Christine Selton-...; Pascale Raud-Raynier; Guillaume Jondeau; Nicolas Mansencal; Caroline Sawka; Flavie Ader; Jean-François Pruny; Anne-Claire Casalta; Nicolas Michel; Valeria Donghi; Laurence Faivre; Roch Giorgi; Philippe Charron; Gilbert Habib
• Keywords: Clinical endpoint; Dilated Cardiomyopathy; Left ventricular noncompaction

Whether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still matter of debate.From multicenter French prospective registry, we compared the outcomes 98 patients with LVNC and 65 DCM. The primary endpoint combined cardiovascular death, heart transplantation, hospitalization for events. two groups presented similar but ejection fractions (LVEF) (43.3% in vs. 35.95% DCM, p = 0.001). For this reason, subgroup analysis was performed comparing only LVEF ≤ 45%, including 56 49 DCM.Among LVEF≤ at 5-year follow-up, occurred 33 (58.9%) among 18 (36.7%) DCM (p 0.02). Hospitalization failure (18 [32.14%] 5 [10.20%], 0.035) transplantation were more frequent group. incidences rhythmic complications (24 [42.85%] 12 [24.48%], 0.17), embolic events, death between cases. Among 42 > endpoints 4 (9.52%) patients, 2 hospitalizations 3 complications, no events.In cohort, who have dysfunction present poorer patients. Heart events especially frequent, not. Patients preserved fraction very few years.