Therapeutic Effect of Pericytes for Diabetic Wound Healing

• DOI: 10.3389/fcvm.2022.868600
• Publication Date: 2022-05-13T05:02:04Z
• Authors: Kyeong Mi Kim; Hyun-Ju An; Sang-Hoon Kim; JuHee Kim; Changgon Sim; Jaemin Lee; Sin Hyung Park; Hyun Il Lee; Inseok Jang; Soonchul Lee
• Keywords: 0301 basic medicine; angiogenesis; 03 medical and health sciences; pericyte; RC666-701; diabetes mellitus; Diseases of the circulatory (Cardiovascular) system; wound healing; ischemic foot ulcer; Cardiovascular Medicine; 3. Good health

ObjectiveNumerous attempts have been made to devise treatments for ischemic foot ulcer (IFU), which is one of the most severe and fatal consequences of diabetes mellitus (DM). Pericytes, which are perivascular multipotent cells, are of interest as a treatment option for IFU because they play a critical role in forming and repairing various tissues. In this study, we want to clarify the angiogenic potential of pericytes in DM-induced wounds.MethodsWe evaluated pericyte stimulation capability for tube formation, angiogenesis, and wound healing (cell migration) in human umbilical vein endothelial cells (HUVECs) with in-vivo and in-vitro models of high glucose conditions.ResultsWhen HUVECs were co-cultured with pericytes, their tube-forming capacity and cell migration were enhanced. Our diabetic mouse model showed that pericytes promote wound healing via increased vascularization.ConclusionThe findings of this study indicate that pericytes may enhance wound healing in high glucose conditions, consequently making pericyte transplantation suitable for treating IFUs.