D-Dimer Is a Diagnostic Biomarker of Abdominal Aortic Aneurysm in Patients With Peripheral Artery Disease

• DOI: 10.3389/fcvm.2022.890228
• Publication Date: 2022-06-03T06:22:50Z
• Authors: Huoying Cai; Baihong Pan; Jie Xu; Shuai Liu; Lei Wang; Kemin Wu; Pu Yang; Jianhua Huang; Wei Wang
• Keywords: Mean platelet volume; D-dimer

Background Etiology and risk factors of peripheral artery disease (PAD) include age, smoking, hypertension, etc. , which are shared by an abdominal aortic aneurysm (AAA). Concomitance with AAA in patients PAD is not rare but easily overlooked the clinical situation, though management strategies altered totally. This study aims to investigate diagnostic biomarkers for prediction PAD. Methods A total 684 diagnosed and/or were enrolled analyzed retrospectively. Each patient was gender age-matched. Demographic data, medical history, serum laboratory test profiles obtained. Statistical analysis performed determine Results Firstly, 320 PAD-only AAA-only compared. Levels bilirubin D-Dimer decreased, while incidence diabetes mellitus, levels fibrinogen, platelet count increased significantly compared those ( P < 0.001). Next, 364 (44 AAA) PAD) Multivariate logistic regression confirmed differential distribution bilirubin, D-dimer, between 0.05). Receiver operator curves (ROC) showed that area under curve (AUC) direct 0.6113, 0.5849, 0.7034, 0.6473, 0.6785, respectively. Finally, further validate predictive efficacy mentioned markers, a multivariable logistics only group group. The results suggested D-dimer (OR: 2.630, 95% CI:1.639–4.221; In particular, Youden index cut-off value predicting 0.675 mg/L sensitivity 76.9% specificity 84.9% (AUC = 0.8673; CI, 0.8106–0.9240, all PAD, 41.46% when >0.675 mg/L, 3.55% ≤ mg/L. Conclusions exert different profiles; (>0.675 mg/L) reliable biomarker