Effect of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults: the Shigatse CARdiorespiratory fitness study design

• DOI: 10.3389/fcvm.2023.1129144
• Publication Date: 2023-07-25T17:03:59Z
• Authors: Jie Yang; Xiaowei Ye; Zhen Liu; Mengjia Sun; Shiyong Yu; Hailin Lv; Boji Wu; Chen Zhang; Wenzhu Gu; Jingyu He; Xuhong Wang; Lan Huang
• Keywords: cardiorespiratory fitness; study design; RC666-701; high altitude; ubiquinol; Diseases of the circulatory (Cardiovascular) system; clinical trial; Cardiovascular Medicine; cardiopulmonary exercise test; 3. Good health

Cardiorespiratory function influences exercise capacity and is an important determinant of high-altitude adaptation. Some studies have investigated the characteristics changes in cardiorespiratory fitness during acclimatization. However, on de-acclimatization are still lacking not yet been elucidated. Furthermore, few drugs studied to improve both processes. The Shigatse CARdiorespiratory Fitness (SCARF) study a single-center, randomized, double-blind, placebo-control clinical trial explore effects ubiquinol acclimatization healthy adults. Participants will be randomly assigned 1:1 200 mg daily or placebo for 14 days before departure until end data collection after return 7 days. primary outcome, while acute mountain sickness symptoms secondary endpoints. In addition, laboratory measurements, including routine blood tests serological performed. To best our knowledge, SCARF first reveal de-acclimatization. results this contribute exploring whether supplementation could beneficial endurance at different altitudes help adaptation hypoxia Clinical Trial Registration: This has registered Chinese Register (www.chictr.org.cn) as ChiCTR2200059900 ChiCTR2200066328.