Outcomes among patients undergoing transcatheter aortic valve replacement with very low baseline gradients

• DOI: 10.3389/fcvm.2023.1194360
• Publication Date: 2023-08-04T12:11:25Z
• Authors: Faisal Rahman; Hetal H. Mehta; Jon R. Resar; Rani K. Hasan; Wendy Marconi; Hamza Aziz; Matthew J. Czarny
• Keywords: Baseline (sea); Valve replacement

Background While there is evidence that patients with low-flow, low-gradient aortic stenosis (AS) benefit from transcatheter valve replacement (TAVR), data are lacking regarding outcomes of a very low gradient (VLG). Methods In this retrospective, single-center study severe AS who underwent TAVR, three groups were defined using baseline mean gradient: VLG (≤25 mmHg), (LG, 26–39 and high (HG, ≥40 mmHg). The primary outcome was the composite Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 <45, decrease in KCCQ-12 ≥10 compared baseline, or death at 1 year. Results One-thousand six included: 571 HG, 353 LG, 82 VLG. median age 82.1 years [interquartile range (IQR) 76.3–86.9]; had more comorbidities other groups. highest year group (VLG, 46.7%; 29.9%; 23.1%; p = 0.002), no difference between after adjustment for characteristics. At <30% an excellent good (50–100) KCCQ-12, whereas than 75% 50% 30-day 1-year follow-up, respectively. Conclusion Although undergoing TAVR have higher rate poor LG HG AS, largely attributable to comorbidities. Patients significant improvement health status regardless resting gradient.