Galectin-3 and peripheral artery disease: a Mendelian randomization study

• DOI: 10.3389/fcvm.2023.1279396
• Publication Date: 2024-01-04T05:08:10Z
• Authors: Yang Gou; Miao Chen; Zhi Zhu; Chi Cui
• Keywords: Mendelian Randomization

Background Multiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis severity of peripheral arterial disease (PAD). The current study used Mendelian randomization (MR) technique to evaluate possible causal relationship Gal-3 PAD. Methods Genome-wide association (GWAS) data PAD were obtained through MR-Base platform. Then, using as exposure outcome, two-sample MR analysis was performed utilizing several regression techniques, including MR-Egger regression, inverse variance weighted (IVW), median, mode. Results Six single-nucleotide polymorphisms (SNPs) identified designated instrumental variables (IVs) that exhibited correlations with (linkage disequilibrium r 2 < 0.001; P 5 × 10 −8 ). Various statistical methods showed there an absence link (IVW: odds ratio (OR) = 0.9869, 95% confidence interval (CI) 0.8792–1.1078, 0.8232). In addition, presence genetic pleiotropy did impact putative (MR-Egger intercept 0.0099, 0.659). Conclusions There is no evidence establish level