The inflammatory spectrum of cardiomyopathies

• DOI: 10.3389/fcvm.2024.1251780
• Publication Date: 2024-02-23T14:38:21Z
• Authors: Nicolas Musigk; Phillip Suwalski; Ainoosh Golpour; DeLisa Fairweather; Karin Klingel; Pilar Martin; Andrea Frustaci; Leslie T. Cooper; Thomas F. Lüscher; Ulf Landmesser; Bettina Heidecker
• Keywords: 11459 Center for Molecular Cardiology; RC666-701; 610; heart failure; Diseases of the circulatory (Cardiovascular) system; 610 Medicine & health; endomyocardial biopsy (EMB); myocarditis; Cardiovascular Medicine; inflammatory cardiomyopathy; cardiomyopathy; 2705 Cardiology and Cardiovascular Medicine

Infiltration of the myocardium with various cell types, cytokines and chemokines plays a crucial role in the pathogenesis of cardiomyopathies including inflammatory cardiomyopathies and myocarditis. A more comprehensive understanding of the precise immune mechanisms involved in acute and chronic myocarditis is essential to develop novel therapeutic approaches. This review offers a comprehensive overview of the current knowledge of the immune landscape in cardiomyopathies based on etiology. It identifies gaps in our knowledge about cardiac inflammation and emphasizes the need for new translational approaches to improve our understanding thus enabling development of novel early detection methods and more effective treatments.