Lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients in non-metropolitan areas of Brandenburg, Germany

• DOI: 10.3389/fcvm.2024.1302152
• Publication Date: 2024-03-07T00:04:15Z
• Authors: Philipp Hillmeister; Kangbo Li; Mengjun Dai; Mesud Sacirovic; Nikolaos Pagonas; Oliver Ritter; Peter Bramlage; Anja Bondke Persson; Ivo Buschmann; Claudia Zemmrich
• Keywords: Lipoprotein(a); Atherosclerotic cardiovascular disease

Background and aims In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates cardiovascular diseases underserved medical care, there a lack awareness regarding lipoprotein(a) [Lp(a)] as risk factor. addition, data from patients with atherosclerotic disease (ASCVD) in diverse regional backgrounds, including understudied cohort, various healthcare statuses remain insufficient. Methods this WalkByLab study, Lp(a) levels were monitored cohort ( n = 850) Brandenburg, Germany, comprising 533 at 317 healthy controls. Patients underwent comprehensive angiological screening, included blood serum analysis, assessment family history, risk, status, evaluation lifestyle quality life. All parameters evaluated regard to two groups based on levels: low (<50 mg/dl) (≥50 mg/dl). Results showed higher than controls (24.2% vs. 14.8%, p 0.001). Logistic regression analysis different characteristics revealed that was an independent factor significantly associated ASCVD (OR 2.26, 95% CI 1.32–3.95, 0.003). The high-Lp(a) group proportion coronary artery disease, peripheral or cerebrovascular compared low-Lp(a) (50% 36.8%; 57.7% 45.8%; 17.6% 9.2%; 0.004); also, percentage had heart failure (72.8% 53.2%, 0.014) myocardial infarction (24.7% 13.9%, exhibited statins (63.1% 50.4%, 0.003), ezetimibe (14.8% 5.5.%, 0.001), beta-blockers (55.7% 40.7%, 0.001) use. found be physical activity smoking behavior did not change over time (12 months). Conclusions Our study highlights significance elevated identifies them for ASCVD, has implications addressing health populations.