The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

• DOI: 10.3389/fcvm.2024.1345218
• Publication Date: 2024-02-02T04:38:41Z
• Authors: Rosamaria Caminiti; Cristina Carresi; Rocco Mollace; Roberta Macrì; Federica Scarano; Francesca Oppedisano; Jessica Maiuolo; Maria Serra; Stefano Ruga; Saverio Nucera; Annamaria Tavernese; Micaela Gliozzi; Vincenzo Musolino; Ernesto Palma; Carolina Muscoli; Speranza Rubattu; Maurizio Volterrani; Massimo Federici; Massimo Volpe; Vincenzo Mollace
• Keywords: Endothelial Dysfunction; Pathophysiology of hypertension; Pathophysiology

Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, the identification effective solutions for treating early stages elevated blood pressure (BP) is still relevant issue risk prevention. The pathophysiological basis occurrence BP onset arterial have been widely studied in recent years. In addition, consistent progress development novel, powerful, antihypertensive drugs their appropriate applications controlling increased our potential successfully managing disease states characterized by abnormal pressure. However, mechanisms responsible disruption endogenous contributing to maintenance within normal range are yet be fully clarified. Recently, evidence has shown that several natural antioxidants containing active ingredients originating from plant extracts, used alone or combination, may represent valid solution counteracting hypertension. particular, there show enhance viability endothelial cells undergoing oxidative damage, an effect could play crucial role events accompanying present review aims reassess stress on dysfunction progression covering unmet needs treatment such diseases.