Gastroesophageal reflux disease may causally associate with the increased atrial fibrillation risk: evidence from two-sample Mendelian randomization analyses

• DOI: 10.3389/fcvm.2024.1393383
• Publication Date: 2024-06-03T17:26:31Z
• Authors: Lei Wang; Yi Wei Lu
• Keywords: Mendelian Randomization; Genome-wide Association Study; Genetic Association; Pleiotropy

Background The risk of atrial fibrillation (AF) is increased in individuals with gastroesophageal reflux disease (GERD), according to observational research. causal significance this association still unclear. This study sought assess GERD's role as a potential contributing factor AF. Methods With the use two-sample Mendelian randomization (MR) technique, we assessed relationship between GERD and genetic variants was examined using data from recent genome-wide (GWAS) that included 602,604 people. Data on variations AF obtained second GWAS 1,030,836 participants. effect sizes were based inverse-variance weighted method. Additional statistical techniques, including MR-Egger, simple mode, MR Pleiotropy Residual Sum, outlier, median used sensitivity analysis. Results analyses models, 76 single nucleotide polymorphisms (SNPs) markers, revealed genetically predicted greater incidence [odds ratio (OR): 1.165, 95% CI 1.102–1.231; P = 7.637 × 10 −8 ]. According there no evidence gene pleiotropy could be found (intercept 0.003, 0.581). findings study, which several methods, reliable. Conclusion analysis correlation incidence, supporting idea treating patients early possible might reduce their chance developing