The association between blood urea nitrogen to serum albumin ratio and 28 day in-hospital mortality in patients with chronic heart failure and sepsis: a pilot retrospective study

• DOI: 10.3389/fcvm.2025.1491331
• Publication Date: 2025-03-04T07:12:38Z
• Authors: Ali Ma; Chen Zhang; Ying Gong; Xueping Ma; Ning Yan

Aims The purpose of this study was to explore the relationship between blood urea nitrogen serum albumin ratio and 28-day in-hospital mortality in patients with chronic heart failure complicated by sepsis admitted intensive care unit (ICU). Methods This retrospective included 723 from eICU database. Smooth curve fitting assessed association BAR mortality. Multivariable Cox regression analysis conducted calculate adjusted hazard (HR) 95% confidence interval (CI). Kaplan–Meier curves compared survival rates across tertile s . Subgroup stratified based on relevant covariates a forest plot drawn verify stability results. Results Among sepsis, rate 20.33% (147/723). After adjusting for confounders, as categorical variable, highest had significantly higher death risk than those lowest [HR: 1.87, CI (1.09,3.19), p : 0.023]. When continuous each increase raised in—hospital 2% 1.02, (1.01, 1.04), = 0.0038]. Stratified showed no interaction, E—value indicated robustness unmeasured confounding, highlighting stable significant 28—day these patients. Conclusion In context critically ill there exists correlation (BAR) Specifically, levels are associated an elevated However, findings require further research confirmation.