Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study

• DOI: 10.3389/fendo.2022.934020
• Publication Date: 2022-07-26T05:21:43Z
• Authors: Yifan Cheng; Wen Cao; Junzhe Zhang; Jiabin Wang; Xiang Liu; Qianqian Wu; Qingxia Lin
• Keywords: Univariate analysis

Background In this study, we investigated the epidemiological characteristics and predictors of diabetic peripheral neuropathy (DPN) in adult patients with type 2 diabetes mellitus (DM). Methods The study was designed as a retrospective cohort trial at First Affiliated Hospital Wenzhou Medical University. From January 2017 to December 2020, total 1,262 DM were enrolled assess risk factors for DPN. divided into two groups (DPN group non-DPN group). Mann–Whitney U test or t -test, receiver operating characteristic (ROC) analyses, univariate chi-square multiple logistic regression analyses used analyze adjusted Results overall prevalence DPN 72.7% ( n = 793/1,091). Multivariate analysis revealed that age > 66 years (odds ratio [OR], 2.647; 95% confidence interval [CI] 1.469–4.770; p 0.002), history hypertension (OR, 1.829; CI 1.146–2.920; 0.011), neutrophil (NE) levels exceeding 4.0 × 10 9 /L (OR 0.256; 0.162–0.405; 0.001), lymphocyte (LY) over 3.0 7.173; 4.258–12.086; 0.000), HbA1c 7.7% 3.151; 1.959–5.068; FT3 4.4 pmol/L 0.417; 0.263–0.662; 0.000) six significant predictive Conclusions High LY, HbA1c, hypertension, increase DM, while high NE protective Thus, prediction can significantly be improved by identifying older well establishing biochemical cutoff values NE, FT3.