The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis

• DOI: 10.3389/fendo.2023.1127425
• Publication Date: 2023-03-28T05:43:05Z
• Authors: Leigang Wang; Yao Zhang; Bing Yu; Jianqi Zhao; Wenjing Zhang; Hongxuan Fan; Zhaoyu Ren; Bin Liang
• Keywords: nonalcoholic fatty liver disease; Inflammation; monocyte to high-density lipoprotein cholesterol ratio; Cholesterol, HDL; RC648-665; Diseases of the endocrine glands. Clinical endocrinology; Monocytes; 3. Good health; propensity score matching analysis; Endocrinology; inflammation; Non-alcoholic Fatty Liver Disease; Atrial Fibrillation; Humans; atrial fibrillation; Lipoproteins, HDL; Retrospective Studies

Background Accumulating evidence suggests that patients with nonalcoholic fatty liver disease (NAFLD) have a significantly high risk of incident atrial fibrillation (AF). Systemic inflammation, metabolic disorders and oxidative stress could be the potential mechanisms by which NAFLD drives AF. Monocyte-to- high-density lipoprotein ratio (MHR) has emerged as novel biomarker inflammation not been studied in AF patients. We aimed to investigate relationship between MHR among Methods A retrospective analysis was performed for clinical data Second Hospital Shanxi Medical University from January 2019 October 2022, whom 204 were enrolled NAFLD+AF group 613 without control, 152 selected each based on propensity score matching (PSM) at 1:1 balance covariates groups. The t-test or Mann-Whitney U test used comparison continuous two groups; chi-square Fisher’s exact categorical Logistic regression identify independent predictor occurrence Trend analyze prevalence tertiles, then correlation confirmed restricted cubic splines (RCS). receiver operating characteristic (ROC) curve determine optimum cutoff value predict Results Univariate showed had higher than non-AF (P < 0.001). Meanwhile, compared pure patients, multivariate logistic remained an factor after adjusting confounding factors (OR = 10.67, 95% CI 2.17-52.37, P 0.004). TC、HDL-C also Among them, TC HDL-C are protective trend increased increase 0.05). However, RCS nonlinear J-shaped non-linearity 0.023). increasing only when > 0.44. ROC combined traditional can improve ability Conclusion is independently associated show certain predictive value.