Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene

• DOI: 10.3389/fendo.2023.1281112
• Publication Date: 2023-12-07T13:50:56Z
• Authors: Durmus Doğan; Eda Gül Özcan; Dilek Ülker Çakır; Fatma Sılan
• Keywords: Vitamin D-binding protein

Introduction Vitamin D binding protein (VDBP) plays a crucial role in vitamin transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP 25-hydroxyvitamin (25OHD) levels. However, mechanisms underlying these effects remain unclear. We aimed to investigate relationship between urinary excretion 25OHD levels individuals without allele. Methods A cross-sectional study was conducted on 109 children (mean age: 11.96 years) explore impact metabolism excretion. Biochemical analyses determined levels, VDBP-to-creatinine ratio (u-VDBP/Cr). Genotyping for rs4588 SNP performed using LightSNiP assay. Statistical included correlation, linear regression, comparison allele groups. Results Participants carrying exhibited lower compared non-carriers (median (IQR): 11.85 (3.5) vs. 12.86 (4.9), p = 0.023). no statistically significant differences were observed (126.34 ± 59.3 136.49 51.3 non-rs4588-A, 0.141) or u-VDBP/Cr 0.4 (0.35) 0.386 (0.43) 0.189) two inverse correlation found only carriers (r -0.367, 0.024). No such entire cohort. regression analysis confirmed (B -0.269, t -2.185, 0.035). Conclusion Individuals gene had An observed, suggesting partial renal pathway linked