Exploring the bidirectional relationship between metabolic syndrome and thyroid autoimmunity: a Mendelian randomization study

• DOI: 10.3389/fendo.2024.1325417
• Publication Date: 2024-03-19T04:19:31Z
• Authors: Kefan Chen; Wei Sun; Liang He; Wenwu Dong; Dalin Zhang; Ting Zhang; Hao Zhang
• Keywords: Mendelian Randomization; Genetic Association

Background Observational studies have reported a possible association between metabolic syndrome (MetS) and thyroid autoimmunity. Nevertheless, the relationship autoimmunity MetS remains unclear. The objective of this research was to assess causal impact on through utilization Mendelian randomization (MR) methodology. Methods We performed bidirectional MR elucidate their components (positivity TPOAb). Single nucleotide polymorphisms (SNPs) its were obtained from publicly available genetic variation summary database. Thyroidomics Consortium conducted genome-wide analysis, which provided summary-level data pertaining study included several statistical methods, including inverse variance weighting method (IVW), weighted median, simple mode, weight MR-Egger link. In addition, ensure stability results, sensitivity analysis conducted. Results IVW showed that reduced risk developing (OR = 0.717, 95% CI 0.584 - 0.88, P 1.48E−03). investigation into causative autoimmune revealed statistically significant link triglycerides levels presence (IVW OR 0.603, 95%CI 0.45 -0.807, 6.82E−04). reverse did not reveal any MetS, five components. Conclusions presented new evidence demonstrating triglyceride may serve as potential protective factors against