Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals

• DOI: 10.3389/fendo.2024.1331012
• Publication Date: 2024-03-14T04:24:53Z
• Authors: Gustavo Daher; Daniele Pereira S...; Ana Mercedes Cava...; Tatiana Souza Pelaes; Sharon Nina Admoni; Ricardo Vessoni P...; Cleide Guimarães ...; Fernanda Gaspar d...; José Cipolla-Neto; Maria Lúcia Corre...
• Keywords: SNP

Aim The pathogenesis of chronic diabetes complications has oxidative stress as one the major elements, and single-nucleotide polymorphisms (SNPs) in genes belonging to antioxidant pathways modulate susceptibility these complications. Considering that melatonin is a powerful compound, our aim was explore, longitudinal cohort study type 1 (T1D) individuals, association microvascular SNPs gene encoding receptor 1A ( MTNR1A ). Methods Eight were genotyped 489 T1D individuals. Besides cross-sectional analyses with each (distal polyneuropathy, cardiovascular autonomic neuropathy, retinopathy, diabetic kidney disease), analysis evaluated associations renal function decline 411 individuals followed up for median 8 years. In subgroup participants, urinary 6-sulfatoxymelatonin (aMT6s) concentration investigated. Results group ≥ 5 mL min −1 1.73 m −2 year presented higher frequency A allele rs4862705 comparison nondecliners, even after adjustment confounding variables (OR = 1.84, 95% CI 1.20–2.82; p 0.0046). No other significant found. Conclusions This first showing an between variant system setting.