Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China

• DOI: 10.3389/fendo.2024.1361479
• Publication Date: 2024-09-24T04:25:28Z
• Authors: Yaling Yang; Lifang Qian; Chenwei Wu; Xinyue Xu; Duoduo Qu; Lihua Zhou; Jia Liu; Qin Zhu; Chunhong Wang; Xiaolong Zhao
• Keywords: Male; Adult; China; Thyroid Hormones; non-thyroid illness syndrome; Thyroid Gland; severe COVID-19; Thyroid Function Tests; Severity of Illness Index; Diseases of the endocrine glands. Clinical endocrinology; Cohort Studies; Endocrinology; Hypothyroidism; Humans; Retrospective Studies; Aged; thyroid function; SARS-CoV-2; COVID-19; Middle Aged; RC648-665; Prognosis; Euthyroid Sick Syndromes; Thyrotoxicosis; total triiodothyronine; Female

Objective This study aims to examine the thyroid hormone profile and its association with severe coronavirus disease 2019 (COVID-19) in patients infected by acute respiratory syndrome 2 (SARS-CoV-2). Methods retrospective cohort enrolled admitted a tertiary hospital due SARS-CoV-2 infection between February 18 May 18, 2022. Clinical data were collected retrospectively from electronic medical record system. Based on function, divided into five groups: normal, non-thyroid illness (NTIS), hypothyroidism, thyrotoxicosis, unclassified. The function COVID-19 was detected using multivariable logistic regression restricted cubic splines analysis. Results included 3,161 patients, 7.7% of them developing COVID-19. 44.9% had normal 36.5% NTIS, 6.7% 1.0% thyrotoxicosis admission. After adjusting for age, sex, relevant clinical characteristics, NTIS hypothyroidism associated increased risks (odds ratio [OR] 2.38, 95% confidence interval [CI] 1.59-3.56 OR 2.29, CI 1.23-4.26, respectively), compared group. Among or higher levels total triiodothyronine (TT3) are lower (OR 0.73, 0.64-0.82, every 0.1nmol/L increase TT3 level). Conclusion Thyroid profiles decreased level correlated risk hypothyroidism.