Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences

• DOI: 10.3389/fendo.2024.1397512
• Publication Date: 2024-04-30T06:45:43Z
• Authors: Yu Chang; Fan Li; Zhi Wang; Qi Zhao; Zhaodi Wang; Xiaoping Han; Zifeng Xu; Chanjiao Yu; Yue Liu; Shiyu Chang; Hongyan Li; Sileng Hu; Yuqin Li; Tongyu Tang
• Keywords: Male; Adult; antioxidant; colorectal cancer; Diseases of the endocrine glands. Clinical endocrinology; 03 medical and health sciences; Endocrinology; Risk Factors; Humans; Prospective Studies; oxidative balance score; mediation analysis; Life Style; Aged; 0303 health sciences; Incidence; UK biobank; Middle Aged; RC648-665; United Kingdom; Diet; Uric Acid; Oxidative Stress; Female; Colorectal Neoplasms; Follow-Up Studies

Background The Oxidative Balance Score (OBS) is commonly used to assess oxidative stress and provides a comprehensive evaluation of dietary lifestyle-related exposures. However, there limited research on the association between OBS colorectal cancer (CRC), its subsites, complications. objective this study was relationship risk CRC, common complications in large prospective cohort study. Methods We included data from 175,808 participants UK Biobank sample repository 2006 2010. evaluated using scoring system based 22 lifestyle factors. Multiple adjustments, including multivariate Cox proportional hazard regression, gender stratification, subgroup analysis, sensitivity were performed fully explore mediation analysis conducted investigate whether serum albumin, uric acid, neutrophil levels mediate CRC. Results After adjusting for potential confounding factors, significant negative correlation found CRC subsites (proximal colon cancer, distal rectal cancer). This particularly pronounced male patients. Serum count, which are biomarkers, have mediating effect Conclusion Our suggests that higher exposure antioxidants assessed through (diet rich antioxidants) may decrease occurrence subsites.