Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats

• DOI: 10.3389/fenvh.2023.1166918
• Publication Date: 2023-05-31T10:22:57Z
• Authors: W. Kyle Martin; M. C. Schladweiler; W. Oshiro; J. Smoot; A. Fisher; W. Williams; M. Valdez; C. N. Miller; T. W. Jackson; D. Freeborn; Y. H. Kim; D. Davies; M. Ian Gilmour; U. Kodavanti; P. Kodavanti; M. S. Hazari; A. K. Farraj
• Keywords: Sleep; PER2

Introduction As a lifestyle factor, poor sleep status is associated with increased cardiovascular morbidity and mortality may be influenced by environmental stressors, including air pollution. Methods To determine whether exposure to pollution modified effects of disruption, we evaluated the single or repeated (twice/wk for 4 wks) inhalation eucalyptus wood smoke (ES; 964 µg/m 3 1 h), key wildland fire source, on mild loss in form gentle handling rats. Blood pressure (BP) radiotelemetry echocardiography were along assessments lung systemic inflammation, cardiac hypothalamic gene expression, heart rate variability (HRV), measure autonomic tone. Results Discussion GH alone disrupted sleep, as evidenced active period-like locomotor activity, increases BP, (HR), expression circadian Per2 . A bout disruption ES, but neither alone, HR BP rats transitioned into their period, period aligned critical early morning window stroke risk humans. These responses immediately preceded reduced HRV, indicating sympathetic In addition, only exposed ES had during final period. also output genes related adrenergic function, regulation vasoconstriction blood one day after exposure. There was little evidence except serum LDL cholesterol alanine aminotransferase. results suggest that inhaled perturbation-related risk, potentially part activity.