Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis

• DOI: 10.3389/fgene.2021.625846
• Publication Date: 2021-01-28T08:39:50Z
• Authors: Bing Wang; Jun Wu; Qilin Huang; Xiaohui Yuan; Yi Yang; Wen Jiang; Yi Wen; Lijun Tang; Hongyu Sun
• Keywords: Competing Endogenous RNA; KEGG; Circular RNA

Severe acute pancreatitis (SAP) is an digestive system disease with high morbidity mortality and hospitalization rate worldwide, due to various causes unknown pathogenesis. In recent years, a large number of studies have confirmed that non-coding RNAs (ncRNAs) play important role in many cellular processes occurrence. However, the underlying mechanisms based on function ncRNAs, including long noncoding RNA (lncRNA) circular (circRNA), SAP remain unclear. this study, we performed high-throughput sequencing pancreatic tissues three normal mice for first time describe analyze expression profiles lncRNA circRNA. Our results identified 49 lncRNAs, 56 circRNAs 1,194 mRNAs were differentially expressed group, compared control group. Furthermore, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis lncRNAs circRNAs, found functions parental genes are enriched calcium-regulated signaling pathway, NF-κB autophagy protein digestion absorption processes, which closely related central events pathogenesis SAP. We also constructed lncRNA/circRNA-miRNA-mRNA networks further explore their mechanism possible relationships competitive endogenous (ceRNA) networks, mainly involved apoptosis pathway calcium signal transduction pathway. conclusion, SAP, may provide new insights exploring seek targets