A Novel Prognostic Biomarker of Luminal Breast Cancer: High CD39 Expression Is Related to Poor Survival

• DOI: 10.3389/fgene.2021.682503
• Publication Date: 2021-06-18T06:46:50Z
• Authors: Xiaojian Ni; Wenze Wan; Jingjing Ma; Xinyou Liu; Bohao Zheng; Zhixian He; Weige Yang; Lihong Huang
• Keywords: 0303 health sciences; 03 medical and health sciences; breast cancer; nucleoside triphosphate diphosphohydrolase-1; Genetics; The Cancer Genome Atlas; prognosis; tumor immunology; QH426-470; 3. Good health

CD39 is one of the functional surface markers for T regulatory cells, prognostic role and immune-related effects in luminal breast cancer (BC) patients has not been evaluated yet. The aim current study was to explore association between expression clinic pathological characteristics prognosis BC patients.Clinical information RNA-sequencing (RNA-Seq) data were extracted from Cancer Genome Atlas (TCGA). Patients divided into a high or low group by optimal cutoff value (4.18) identified receiver operating characteristic curve analysis. relationships features corresponding statistical tests. Survival analyses applied evaluate overall survival groups BC. Furthermore, Gene Expression Omnibus datasets used external validation. set enrichment analysis (GSEA) also performed, CIBERSORT analyze immune cell populations.Analysis 439 cases tumor showed that overexpressed multivariable suggested an independent factor patients. GSEA might play important progression through regulation. Analysis patterns revealed correlated higher proportion CD8+ cells M2 macrophages.This demonstrates correlates with TCGA database mining. Further studies are warranted further elucidate this potential novel therapeutic strategy