Identification and validation of N6-methyladenosine (m6A)-related lncRNAs signature for predicting the prognosis of laryngeal carcinoma, especially for smoking patients

• DOI: 10.3389/fgene.2023.1292164
• Publication Date: 2023-11-09T16:14:58Z
• Authors: Yuqing Chen; Chenyu Chen; Gufeng Gao; Chaojun Zeng; Zhifeng Chen; Gongbiao Lin; Guangnan Yao; Shenqing Nian; Xihang Chen; Simin Weng; Xi Gu; Chang Lin
• Keywords: KEGG; N6-Methyladenosine

Laryngeal cancer (LC), a highly fatal tumor in the head and neck region, has been focus of research recent years. The study LC primarily focused on role long non-coding RNAs (lncRNAs) regulating gene expression, as they have emerged pivotal factors this biological process. Additionally, reversible RNA modification called N6-methyladenosine (m6A) observed to significant impact expression well. purpose is investigate m6A-related lncRNAs prognosis laryngeal squamous cell carcinoma (LSCC). Specifically, investigation analyzed regulators' patterns mutation, encompassing total 15 regulators. Drawing upon levels prognostic m6A-regulated lncRNAs, two distinct lncRNA clusters were identified. Further analysis revealed differentially expressed between these clusters. In addition studying researchers also examined distribution clinical characteristics microenvironment (TME) relation identified This provided valuable insights into potential associations features LSCC. Through establishment risk model associated with we able further their features, prognosis, immune status. conducted separate LINC00528, smoking, examining its overall survival time, correlated mRNAs, conducting enrichment Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG), well determining sensitivity related drugs. RT-qPCR results indicated an increase LINC00528 among smoking LSCC patients. findings suggest that high level patients may lead more favorable providing new for management treatment patients, particularly those LINC00528. Overall, sheds light implications advancement innovative therapeutic approaches are noteworthy.