Association between gut microbiota and glioblastoma: a Mendelian randomization study

• DOI: 10.3389/fgene.2023.1308263
• Publication Date: 2024-01-04T05:02:27Z
• Authors: Song Wang; Fangxu Yin; Zheng Guo; Rui Li; Wei Sun; Yuchao Wang; Yichen Geng; Chao Sun; Daqing Sun
• Keywords: Mendelian Randomization; Association (psychology); Genome-wide Association Study

Background: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota development GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate potential causal relationship Methods: We utilized summary statistics derived from genome-wide (GWAS) encompassing 211 The GBM scrutinized using Inverse Variance Weighted (IVW), MR-Egger, Median (WM) methods. Cochrane’s Q statistic conduct heterogeneity test. MR-Pleiotropic Residuals Outliers (MR-PRESSO) were applied identify eliminate SNPs with horizontal pleiotropic outliers. Additionally, Reverse MR assess pertinent microbiota. Results: study estimates suggest that nine remain stable, considering sensitivity Among these, family.Peptostreptococcaceae genus.Eubacterium brachy group associated an increased risk GBM, whereas family.Ruminococcaceae , genus.Anaerostipes genus.Faecalibacterium genus.LachnospiraceaeUCG004 genus.Phascolarctobacterium genus.Prevotella7 genus.Streptococcus reduced Following Benjamini Hochberg (BH) correction, (OR = 0.04, 95% CI: 0.01–0.19, FDR 0.003) identified as playing protective role against Conclusion: This groundbreaking first demonstrate modulation family_Ruminococcaceae for treatment holds considerable clinical significance.