Evaluation of bi-directional causal association between periodontitis and benign prostatic hyperplasia: epidemiological studies and two-sample mendelian randomization analysis

• DOI: 10.3389/fgene.2024.1326434
• Publication Date: 2024-04-10T04:56:12Z
• Authors: Haotian Wei; Guangjie Tian; Shendan Xu; Yaqi Du; Minting Li; Yonglan Wang; Jiayin Deng; Changyi Quan
• Keywords: Mendelian Randomization

Background: Periodontitis and benign prostatic hyperplasia (BPH) are all common chronic diseases with higher incidence in middle-aged old men. Several studies have indicated a potential association between periodontitis BPH, although the findings remain inconclusive. However, there is no mendelian randomization (MR) to assess this association. Methods: The 40 men who had received health check-ups were included an epidemiological study. Genetic data of BPH (13118 cases 72799 controls) (3046 195395 from FinnGen project was used perform two-sample MR analysis. inverse-variance weighted (IVW) model identified as primary analytical method, Egger, median, simple mode, mode serving additional approaches. Results: analysis demonstrated lack statistically significant differences prevalence clinical severe group non-severe group. Similarly, found among individuals compared those without. Additionally, Among five models utilized analysis, including IVW model, evidence causal link observed. Conclusion: our investigation do not provide support for relationship BPH.