Coffee and the risk of osteoarthritis: a two-sample, two-step multivariable Mendelian randomization study

• DOI: 10.3389/fgene.2024.1340044
• Publication Date: 2024-02-01T04:41:56Z
• Authors: Wenzheng Zhang; Xuefeng Lei; Yihui Tu; Tong Ma; Tao Wen; Tao Yang; Long Xue; Jiazhong Ji; Huaming Xue
• Keywords: Mendelian Randomization

Purpose: To investigate the potential causal relationship between coffee consumption and osteoarthritis (OA), to disentangle whether body mass index (BMI) Bone mineral density (BMD) mediate this relationship. Methods: We performed two-sample two-step Mendelian randomization (MR) analyses utilizing publicly available genome-wide association studies (GWAS) summary statistics estimate intake OA risk (including knee OA, hip or total OA), as well possible mediating effects of BMI BMD. In addition, data different types (decaffeinated coffee, instant ground coffee—including espresso, filter, etc., other types) were used explore effect type on OA. Results: MR, increased in various sites, with most significant impact observed (KOA) (odds ratio [OR] 2.03, 95% confidence interval [CI] 1.57–2.61, p < 0.001). The self-reported was minimal (OR 1.03, CI 1.01–1.05, = 0.006). Further analysis revealed that only decaffeinated causally associated both KOA 4.40, 1.71–11.33, 0.002) 1.13, 1.02–1.26, 0.022). explained over half intake-all association, while BMD accounted for less than 5% mediation effect. Conclusion: Our study suggests increase playing a role. Decaffeinated appears have greatest compared coffee. Therefore, managing selecting appropriate should be included health management individuals who frequently consume